Share Ownership

Major Shareholders

Top 10 Largest Shareholders*

As of December 31, 2021

Shareholder Shares Held
(thousands of shares)
Shareholding Percentage
(%)
Voting Interest
(%)
Roche Holding Ltd 1,005,670 61.16 61.16
The Master Trust Bank of Japan, Ltd. (Trust Account) 144,080 8.76 8.76
Custody Bank of Japan, Ltd. (Trust Account) 49,225 2.99 2.99
SMBC Nikko Securities Inc. 18,063 1.09 1.09
STATE STREET BANK WEST CLIENT - TREATY 505234 13,782 0.83 0.83
JP MORGAN CHASE BANK 385632 13,706 0.83 0.83
STATE STREET BANK AND TRUST COMPANY 505001 12,815 0.77 0.77
Custody Bank of Japan, Ltd. (Security Investment Trust Account) 10,253 0.62 0.62
SUMITOMO LIFE INSURANCE COMPANY 9,000 0.54 0.54
NORTHERN TRUST CO.(AVFC) SUB A/C AMERICAN CLIENTS 8,871 0.53 0.53

*The Company is excluded from the ten major shareholders listed in the table above, although the Company holds 34,739,943 shares of treasury stock.

Ownership Profile

Ownership Profile
Ownership Profile Shares
(thousands of shares)
Shareholding Percentage
(%)
Shareholders
Roche Holding Ltd 1,005,670 59.89 1
Foreign Corporations except Roche 261,727 15.58 1,064
Financial Institutions (Trust Banks, Insurance Companies) 247,014 14.71 87
Individuals and Other 74,604 4.44 88,723
Financial Instruments Firm (Securities Firms) 43,126 2.56 78
Other Corporations 12,173 0.72 592
Treasury stock 34,739 2.06 1

Number of Shareholders

Number of shareholders 20,732 in 2017, 19,947 in 2018, 19,752 in 2019, 34,921 in 2020, 90,546 in 2021

Purchase of Treasury Stock

Acquisition Period Shares Acquired
(thousands of shares)
Total Acquisition Cost (Yen) Average Cost per Share (Yen)
2007 Feb. 8 - Mar. 20 9,500 27,583,568,000 2,904
2004 Oct. 10 - Nov. 16 1,000 1,642,702,200 1,643
2003 Aug. 28 - Sep. 5 800 1,024,559,600 1,281
Jul. 28 2,000 2,780,000,000 1,390
Jun. 26 1,500 2,044,500,000 1,363
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Shareholder Information

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