Share Ownership

Major Shareholders

Top 10 Largest Shareholders*

As of December 31, 2022

Shareholder Shares Held
(thousands of shares)
Shareholding Percentage
(%)
Voting Interest
(%)
Roche Holding Ltd 1,005,670 61.13 61.14
The Master Trust Bank of Japan, Ltd. (Trust Account) 148,700 9.03 9.04
Custody Bank of Japan, Ltd. (Trust Account) 61,476 3.73 3.73
SMBC Nikko Securities Inc. 19,524 1.18 1.18
JPMorgan Securities Japan Co., Ltd. 15,441 0.93 0.93
STATE STREET BANK WEST CLIENT - TREATY 505234 14,445 0.87 0.87
STATE STREET BANK AND TRUST COMPANY 505001 14,111 0.85 0.85
NORTHERN TRUST CO.(AVFC) SUB A/C AMERICAN CLIENTS 11,266 0.68 0.68
SUMITOMO LIFE INSURANCE COMPANY 9,000 0.54 0.54
JP MORGAN CHASE BANK 385781 8,755 0.53 0.53

*The Company is excluded from the ten major shareholders listed in the table above, although the Company holds 34,037,098 shares of treasury stock.

Ownership Profile

Ownership Profile
Ownership Profile Shares
(thousands of shares)
Shareholding Percentage
(%)
Shareholders
Roche Holding Ltd 1,005,670 59.89 1
Financial Institutions (Trust Banks, Insurance Companies) 251,355 14.97 93
Foreign Corporations except Roche 251,153 14.95 1,073
Individuals and Other 72,088 4.29 81,830
Financial Instruments Firm (Securities Firms) 55,672 3.31 61
Other Corporations 9,079 0.54 516
Treasury stock 34,037 2.02 1

Number of Shareholders

Number of shareholders 19,947 in 2018, 19,752 in 2019, 34,921 in 2020, 90,546 in 2021, 83,575 in 2022

Purchase of Treasury Stock

Acquisition Period Shares Acquired
(thousands of shares)
Total Acquisition Cost (Yen) Average Cost per Share (Yen)
2007 Feb. 8 - Mar. 20 9,500 27,583,568,000 2,904
2004 Oct. 10 - Nov. 16 1,000 1,642,702,200 1,643
2003 Aug. 28 - Sep. 5 800 1,024,559,600 1,281
Jul. 28 2,000 2,780,000,000 1,390
Jun. 26 1,500 2,044,500,000 1,363
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Shareholder Information

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