Development Pipeline
Development pipeline (as of April 25, 2017)
Development Pipeline [
137KB]
137KB]Oncology
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| AF802/RG7853 (CH5424802/ RO5424802) |
Non-small cell lung cancer (NSCLC) [post-crizotinib] | Approved (17/02) Europe |
alectinib Alecensa® Oral |
In-house Alecensa® (Roche) |
ALK inhibitor |
| NSCLC [1st line] # | Filed (17/03) Overseas |
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| RG435 (RO4876646) |
Renal cell carcinoma # | Phase III Multinational study |
bevacizumab Avastin® Injection |
Roche Avastin® |
Anti-VEGF (Vascular Endothelial Growth Factor) humanized monoclonal antibody |
| Malignant pleural mesothelioma # | Development discontinued | ||||
| RG1273 (RO4368451) |
Breast cancer (adjuvant) # | Phase III Multinational study |
pertuzumab Perjeta® Injection |
Roche Perjeta® |
HER2 dimerization inhibitory humanized monoclonal antibody |
| Gastric cancer # | Phase III Multinational study |
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| RG3502 (RO5304020) |
Breast cancer (adjuvant) # | Phase III Multinational study |
trastuzumab emtansine Kadcyla® Injection |
Roche Kadcyla® |
Anti-HER2 antibody-tubulin polymerization inhibitor conjugate |
| GA101/RG7159 (RO5072759) |
Indolent non-Hodgkin’s lymphoma (NHL) | Phase III Multinational study |
obinutuzumab Injection |
Roche Gazyva®/ Gazyvaro® (EU) (Nippon Shinyaku) |
Glycoengineered type II anti-CD20 monoclonal antibody |
| RG7446 (MPDL3280A) |
NSCLC | Filed (17/02) |
atezolizumab Injection |
Roche Tecentriq® |
Engineered anti-PDL1 monoclonal antibody |
| NSCLC (adjuvant) | Phase III Multinational study |
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| Small cell lung cancer (SCLC) | Phase III Multinational study |
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| Urothelial carcinoma | Phase III Multinational study |
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| Muscle invasive urothelial carcinoma (adjuvant) | Phase III Multinational study |
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| Renal cell carcinoma | Phase III Multinational study |
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| Renal cell carcinoma (adjuvant) | Phase III Multinational study |
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| Breast cancer | Phase III Multinational study |
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| Ovarian cancer | Phase III Multinational study |
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| Prostate cancer | Phase III Multinational study |
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| GC33/RG7686 (GC33/ RO5137382) |
Hepatocellular carcinoma | Phase I Multinational study* |
codrituzumab Injection |
In-house (Roche) |
Anti-Glypican-3 humanized monoclonal antibody |
| CKI27 (CKI27) |
Solid tumors | Phase I | Oral |
In-house |
Raf and MEK dual inhibitor |
| Phase I Overseas |
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| RG7596 (RO5541077) |
NHL | Phase I | polatuzumab vedotin Injection |
Roche | Anti-CD79b antibody-drug conjugate |
| RG7604 (GDC-0032) |
Solid tumors | Phase I | taselisib Oral |
Roche | PI3K inhibitor |
| RG7440 (GDC-0068) |
Solid tumors | Phase I | ipatasertib Oral |
Roche/Array BioPharma | AKT inhibitor |
| ERY974 (ERY974) |
Solid tumors | Phase I Overseas |
Injection |
In-house | Anti-Glypican-3/CD3 bispecific antibody |
| RG6078 (GDC-0919) |
Solid tumors | Phase I | Oral |
Roche/NewLink Genetics | IDO inhibitor |
* Multinational studies managed by Chugai
Bone and Joint Diseases
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| ED-71 (ED-71) |
Osteoporosis | Phase III China |
eldecalcitol Edirol® Oral |
In-house | Activated vitamin D3 agent |
Renal Diseases
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| EOS789 (EOS789) |
Hyperphosphatemia | Phase I | Oral |
In-house | - |
| Phase I Overseas |
Autoimmune Diseases
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| MRA/RG1569 (RO4877533) |
Large-vessel vasculitis # | Filed (16/11) |
tocilizumab Actemra® Injection |
In-house Actemra®/ RoActemra® (EU) (Roche) |
Humanized anti-human IL-6 receptor monoclonal antibody |
| Giant cell arteritis # | Filed (16/11) Overseas |
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| Systemic sclerosis # | Phase III Multinational study |
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| SA237/RG6168 (SA237) |
Neuromyelitis optica (NMO) | Phase III Multinational study* |
Injection |
In-house (Roche) |
Anti-IL-6 receptor recycling antibody |
* Multinational studies managed by Chugai
Neurology
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| RG1450 (RO4909832) |
Alzheimer’s disease | Phase III Multinational study |
gantenerumab Injection |
Roche/ MorphoSys |
Anti-amyloid-beta human monoclonal antibody |
| RG7412 (RO5490245) |
Alzheimer’s disease | Phase III Multinational study |
crenezumab Injection |
Roche/ AC Immune |
Anti-amyloid-beta humanized monoclonal antibody |
| RG7916 (RO7034067) |
Spinal muscular atrophy (SMA) | Phase l | Oral |
Roche/ PTC Therapeutics |
SMN2 splicing modifier |
Others
| Development code (Compound number) |
Indication # Additional indication |
Stage (Date) |
Generic name Product name Dosage form |
Origin Overseas name (Collaborator) |
Mode of Action |
|---|---|---|---|---|---|
| ACE910/RG6013 (RO5534262) |
Hemophilia A (Inhibitor) |
Phase III Multinational study |
emicizumab Injection |
In-house (Roche) |
Anti-FIXa/FX bispecific antibody |
| Hemophilia A (Non-inhibitor) |
Phase III Multinational study |
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| RG3637 (RO5490255) |
Idiopathic pulmonary fibrosis | Phase II Multinational study |
lebrikizumab Injection |
Roche | Anti-IL-13 humanized monoclonal antibody |
| CIM331 (CIM331) |
Pruritus in dialysis patients | Phase II | nemolizumab Injection |
In-house |
Anti-IL-31 receptor humanized monoclonal antibody |
| Atopic dermatitis [Development out-licensed to] - Galderma (Overseas) - Maruho (Japan) |
Phase II Multinational study* |
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| URC102 (URC102) |
Gout | Phase II Overseas |
Oral |
In-house/ JW Pharmaceutical (JW Pharmaceutical) |
URAT1 inhibitor |
| PCO371 (PCO371) |
Hypoparathyroidism | Phase I Overseas |
Oral |
In-house | PTH1 receptor agonist |
| SKY59/RG6107 (SKY59) |
Paroxysmal nocturnal hemoglobinuria (PNH) |
Phase I/II Multinational study |
Injection |
In-house (Roche) |
Anti-C5 recycling antibody |
* Multinational studies managed by Chugai
In principle, completion of first dose is regarded as the start of clinical studies in each phase.
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