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Import of Roche products through the Karl Rhode Company in Kobe commences in Japan (1904)
- The Period's Social Trends
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1900: Exposition Universelle in Paris 1901: 1st Nobel Prize Ceremony 1902: The Anglo-Japanese Alliance 1903: Wright Brother's first flight 1904: Russo-Japanese War 1905: Einstein announces Special Theory of Relativity : Treaty of Portsmouth concluded 1909: Assassination of Itou Hirobumi
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Roche scientific division established in Japan; medical representative system introduced (1912)Shohei Ninomiya became the first medical representative in Japan (1912)
- The Period's Social Trends
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1911: Opening of bridge in Nihonbashi (Tokyo) 1912: Death of Emperor Meiji 1914: World War I begins 1917: Russian Revolution 1918: World War I Ends 1919: Treaty of Versailles 1920: League of Nations set up
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Juzo Ueno founded Chugai Shinyaku Co., Ltd. and began the import and sale of medicinal drugs (March 1925)
Commenced drug manufacturing (1927) -
Established NSY, an unlimited partnership company (1924)
- The Period's Social Trends
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1921: Hitler becomes Nazi Party leader 1923: Great Kanto Earthquake 1925: Universal suffrage established : Maintenance of Public Order Act established 1926: Death of Emperor Taisho 1929: The Great Depression
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Company name changed from NSY to Nippon Roche K.K. (May 1932)
- The Period's Social Trends
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1931: The Manchurian Incident occurs 1933: Japan exits the League of Nations 1936: February 26 Incident 1937: The Second Sino-Japanese War begins 1938: The Ministry of Health and Welfare set up : National Mobilization Law announced 1939: The Second World War begins
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Reorganized into a corporation and company name changed to Chugai Pharmaceutical Co., Ltd. (Head Office: Tokyo) (March 1943)Acquired Matsunaga Pharmaceutical Co., Ltd. and constructed the Matsunaga Plant (Hiroshima Prefecture) (April 1944)
Constructed the Kagamiishi Plant (Fukushima Prefecture) (September 1946)
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Operations suspended during World War II; Evacuated to Takasaki (Gunma Prefecture) (1941)Restarted operations at Takasaki Plant (1947)
- The Period's Social Trends
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1941: The Pacific War begins 1942: The Medical Care Protection Law announced 1945: The atomic bomb dropped (Hiroshima, Nagasaki) The unconditional surrender of Japan (end of war) 1946: The Japanese Constitution announced 1948: Pharmaceutical Affairs Bureau established within The Ministry of Health and Welfare 1949: Dr. Hideki Yukawa, the first Japanese person to win the Nobel Prize (Nobel Prize in Physics) 1950: The Korean War begins : Inauguration of National Police Reserve
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Successfully commercialized glucuronic acid, launched detoxication promotion and liver function recovery agent Guronsan® Powder and Injection (July 1951)
Stock listed on the Tokyo Stock Exchange (now Tokyo Stock Exchange, Inc.) (March 1956)Constructed the Ukima Plant (Tokyo) (April 1957)
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Established temporary office in Nihonbashi-Honcho, Tokyo (1951)
Relocated headquarters to Nikkatsu International Hall (April 1953)Constructed Oi Plant; Closed Takasaki Plant (April 1954)
- The Period's Social Trends
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1951: US-Japan Security Treaty : Signing of San Francisco Treaty 1953: Television broadcasts begins 1956: Restoration of diplomatic relations between USSR and Japan 1957: Approval of Japan into the United Nations General Assembly 1958: Tokyo Tower completed 1959: The crown prince marries (currently his majesty the emperor) 1960: The Vietnam War begins
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Constructed a general research laboratory (Takada Research Laboratory, Tokyo) (September 1960)
Established Fukushima Kasei Co., Ltd. (October 1967)The company name changed to Eiko Kasei Co., Ltd. following the merger of Fukushima Kasei Co., Ltd. and Fukuma Kasei Co., Ltd. (November 1969) -
Relocated headquarters to the Kokusai Building in Tokyo; Completed Kamakura Plant (Kanagawa Prefecture) (1967)
- The Period's Social Trends
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1961: Pharmaceutical Affairs Law /Pharmacists Law announced : First manned space flight "The Earth is blue" (Gagarin) 1963: President Kennedy assassinated 1964: The Tokyo Olympics held 1968: The 300 million yen robbery : University of Tokyo riots 1969: The Apollo 11 Moon Landing 1970: Japanese Expo '70 begins
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Launched blood analyzers and reagents, entry into the clinical test drug instrument sector (February 1971)Constructed the Fujieda Plant (Shizuoka Prefecture) (March 1971)
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Completed Fukuroi Plant (Shizuoka Prefecture); Established Diagnostics Division (1971)
Established the Nippon Roche Research Center in Kamakura (Kanagawa Prefecture) (May 1972)
- The Period's Social Trends
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1971: The Dollar Shock 1972: Restoration of Okinawa to Japan : Normalization of Relations between Japan and China : The Sapporo Winter Olympics held 1973: The Oil Shock 1975: Vietnam War ends 1976: Lockheed bribery scandals 1977: Hijacking of JAL airplane 1978: Treaty of Peace and Friendship between Japan and the People's Republic of China
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Constructed the Fuji-Gotemba Research Laboratory (Shizuoka Prefecture) (June 1987)
Acquired Gen-Probe Incorporated (United States) (December 1989) -
Launched Madopar®, an anti-Parkinson's disease agent (February 1980)Launched Rocephin®, a cephem antibiotic agent (August 1986)Launched Furtulon®, an anticancer agent (September 1987)Established Diagnostics Headquarters (March 1988)
- The Period's Social Trends
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1981: Successful launch of the Space Shuttle 1982: The Falklands War 1984: Naomi Uemura climbs Mount McKinley solo 1985: The Equal Opportunity Act for Men and Women 1988: The Recruit scandal 1989: Death of Emperor Showa : The Berlin Wall falls 1990: The Gulf War begins
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Launched Epogin®, a recombinant human erythropoietin, in Japan (April 1990)Constructed the Utsunomiya Plant (Tochigi Prefecture) (October 1990)
Launched Neutrogin®, a recombinant human granulocyte colony stimulating factor (G-CSF), in Japan (December 1991)Converted the London office (opened March 1986) into Chugai Pharma Europe Ltd., an overseas subsidiary (United Kingdom, now a consolidated subsidiary) (January 1994)Established Chugai Biopharmaceuticals, Inc. (United States, now Chugai Pharma USA, LLC., a consolidated subsidiary) (July 1995)Established Chugai Diagnostics Science Co., Ltd. (Tokyo) (March 1997)Established Chugai Pharma Marketing Ltd. (United Kingdom, now a consolidated subsidiary) (December 1997) -
Established Roche Vitamin Japan K.K. (February 1998)Spun-off the Diagnostics Headquarters as Roche Diagnostics K.K. (August 1998)Launched CellCept® an immunosuppressant agent (November 1999)
- The Period's Social Trends
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1991: Collapse of the Soviet Union 1993: The crown prince marries 1995: Great Hanshin Earthquake : Sarin gas attack on the Tokyo subway 1997: The Kyoto Protocol is adopted 1998: The Nagano Winter Olympics held
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Opened the Tsukuba Research Laboratory (Ibaraki Prefecture) (April 2001)
Established Chugai Pharma France S.A.S. (France, now a consolidated subsidiary) (April 2001)Established Chugai USA, Inc. (United States, now a consolidated subsidiary) (March 2002)Transferred all the shares of Chugai Diagnostics Science Co., Ltd. to Fujirebio Inc. (May 2002)Spun-off Gen-Probe Incorporated (September 2002) -
Launched Kytril®, an anti-emetic agent
Launched Tamiflu®, an anti-influenza virus agent (February 2001)Launched Herceptin®, an anticancer agent
Launched Rituxan®, a treatment for non-Hodgkin's lymphoma (June 2001)Merged with Chugai Pharmaceutical Co., Ltd.
(October 2002)
Chugai and Nippon Roche K.K. merged based on a strategic alliance with F. Hoffmann-La Roche Ltd. Roche Holding Ltd. (and two other companies) became the parent company (October 2002)
Closed the Takada Research Laboratory and the Matsunaga Plant (December 2003)
Transferred the OTC (over-the-counter medicines) business to Lion Corporation
Transferred the insecticide manufacturing business of Eiko Kasei Co., Ltd. to Lion Packaging Co., Ltd. (December 2004)
Transferred the insecticide manufacturing business of Eiko Kasei Co., Ltd. to Lion Packaging Co., Ltd. (December 2004)
Closed the Tsukuba Research Laboratory (March 2005)
Launched Actemra®, the world's first treatment for Castleman's Disease (June 2005)
Transferred the Kagamiishi Plant and all stocks of Tohoku Chugai Pharmaceutical Co., Ltd. to Nipro Corporation (June 2005)
Chugai Pharma Manufacturing Co., Ltd. succeeded to the business of manufacturing pharmaceutical products conducted at Chugai's Ukima Plant, Fujieda Plant, Utsunomiya Plant and Kamakura Plant as the result of a company split (May 2006)
Launched Copegus®, an antiviral agent (March 2007)
Launched Avastin®, an anti-cancer agent (June 2007)
Launched Tarceva®, an anti-cancer agent (December 2007)
Actemra® approved in Japan for rheumatoid arthritis (April 2008)
RoActemra® approved in the EU for rheumatoid arthritis (January 2009)
- The Period's Social Trends
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2001: September 11 attacks 2002: East Timor gains independence. First new independent state of the 21st century : 5 of those kidnapped and taken to North Korea return to Japan 2003: The human genome fully mapped 2009: Hatoyama Cabinet formed through a coalition of the Democratic Party of Japan, Social Democratic Party and People's New Party
