CHUGAI PHARMACEUTICAL CO., LTD.

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Share Ownership

Major Shareholders

Top 10 Largest Shareholders*

As of December 31, 2011

Shareholder Shares Issued
(%)
Voting Interest
(%)
Roche Holding Ltd 335,223 59.89 61.62
The Master Trust Bank of Japan, Ltd. (Trust account) 13,637 2.43 2.50
Japan Trustee Services Bank, Ltd. (Trust account) 12,214 2.18 2.24
JPMorgan Chase Bank 385147 5,321 0.95 0.97
Northern Trust Co. (AVFC) Sub A/C American Clients 4,026 0.71 0.74
Tokio Marine & Nichido Fire Insurance Co., Ltd. 4,016 0.71 0.73
State Street Bank and Trust Company 505225 3,854 0.68 0.70
SSBT OD05 OMNIBUS ACCOUNT - TREATY CLIENTS 3,734 0.66 0.68
Chugai Pharmaceutical Employee Shareholders' Association 3,697 0.66 0.67
Mellon Bank, N.A. as Agent for its Client Mellon Omnibus US Pension 3,565 0.63 0.65

*The Company is excluded from the ten major shareholders listed in the table above, although the Company holds 15,494,118 shares of treasury stock.

Ownership Profile

Ownership Profile

Ownership Profile Shares Issued
(%)
Shareholders
Roche Holding Ltd 335,223 59.89 1
Foreign Corporations except Roche 84,100 15.03 425
Financial Institutions (Trust Banks, Insurance Companies) 63,607 11.36 76
Individuals and Other 41,325 7.38 48,698
Other Corporations 6,103 1.09 270
Financial Instruments Firm (Securities Firms) 13,831 2.47 51
Treasury stock 15,494 2.77 1

Number of Shareholders

Number of Shareholders

Purchase of Treasury Stock

Acquisition Period Shares Acquired Total Acquisition Cost (Yen) Average Cost per Share (Yen)
2007 Feb. 8 - Mar. 20 9,500,000 27,583,568,000 2,904
2004 Oct. 10 - Nov. 16 1,000,000 1,642,702,200 1,643
2003 Aug. 28 - Sep. 5 800,000 1,024,559,600 1,281
Jul. 28 2,000,000 2,780,000,000 1,390
Jun. 26 1,500,000 2,044,500,000 1,363